Mutations in Sodium Channel Gene SCN9A and the Pain Perception Disorders

Table 1

Pain disorders and their characteristics.

Disorder	IEM	PEPD	CIP
Inheritance	AD	AD	AR
Channel function	Increased	Increased	Absent
Symptoms	Painful feet and hands (burning) as the response to heat and movement	Burning in rectal, ocular, and mandibular region, skin redness	No pain feeling at all
Most frequent SNPs	F1449V, L858F, L858H A863P, S241T, N395K, I136V, V1316A, G616R, G856D, I848T, I234T, and F216S	M1627K	S459X, I767X, W897X, M899I, and M932L