A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression
Figure 2
(a) Unsupervised clustering of RCC samples based on cytoband summarized SNP data. CH: chromophobe RCC, PA: papillary RCC; ON: oncocytoma, CC: clear cell. With few exceptions, tumors of a given subclass clustered together. Thus, each of the four RCC subtypes has a distinct pattern of cytogenetic alterations. (b) Somatic cytogenetic alteration profiles of RCC subtypes. RCC subtypes are ordered by complexity of molecular cytogenetic alterations. Each bar in the plot is a box with upper and lower bound of the box representing the third (75%, upper bound) and first quantiles (25%, lower bound) over the summarized SNP copy numbers by cgma method. The boxes are ordered from p-arm to q-arm followed by another chromosome. Only the somatic chromosomes are shown here. A positive value stands for gain, while a negative value stands for loss. Each chromosome is assigned a single color different from its neighbor chromosomes.
