A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression

Table 2

Selected large-scale cytogenetic studies of ccRCC tumors.

Studies		Klatte et al.; 09	Beroud et al. 96	Gunawan et al. 01	Toma et al. 08	Yoshimoto et al. 07	Current	Total
Methods		GPG	qPCR	G-Banding	SNP10K	BACPAC	SNP100K
# samples		246	118 (cc only)	118	22	26	42	572
Event	Stage	Number of events/Total Number of samples = percent
−3p	S1	77/121 = 64%	52/77 = 68%	48/49 = 98%			19/22 = 86%	196/269 = 73%
	S2	17/25 = 68%	10/14 = 71%	12/12 = 100%			2/2 = 100%	41/53 = 77%
	S3	53/97 = 55%	15/22 = 68%	33/34 = 97%			14/15 = 93%	115/168 = 68%
	S4	0/3 = 0%	2/5 = 40%	23/23 = 100%			1/1 = 100%	26/32 = 81%
	Sum	147/246 = 60%	79/118 = 67%	116/118 = 98%	20/22 = 91%	21/26 = 81%	36/40 = 90%	419/570 = 74%
+5q	S1			28/49 = 57%			10/22 = 45%	38/71 = 54%
	S2			6/12 = 50%			2/2 = 100%	8/14 = 57%
	S3			23/34 = 67%			7/15 = 47%	30/49 = 61%
	S4			10/23 = 43%			0/1 = 0%	10/24 = 42%
	Sum	82/246 = 33%		67/118 = 57%	10/22 = 45%	15/26 = 58%	19/40 = 47%	193/452 = 43%
−14q	S1	24/121 = 20%	19/77 = 25%	29/49 = 59%			5/22 = 23%	77/269 = 29%
	S2	8/25 = 32%	4/14 = 29%	9/12 = 75%			0/2 = 0%	21/53 = 40%
	S3	36/97 = 37%	8/22 = 37%	22/34 = 65%			7/15 = 47%	73/168 = 43%
	S4	0/3 = 0%	3/5 = 60%	14/23 = 61%			0/1 = 0%	17/32 = 53%
	Sum	68/246 = 28%	34/118 = 29%	74/118 = 63%	8/22 = 36%	9/26 = 35%	12/40 = 30%	205/570 = 36%
+7		64/246 = 26%		22/118 = 19%	7/22 = 32%	9/26 = 35%	17/40 = 42%	119/452 = 26%
−8p		49/246 = 20%		39/118 = 34%			10/40 = 25%	98/404 = 24%
−6q		42/246 = 17%		28/118 = 24%	6/22 = 27%	8/26 = 31%	7/40 = 17%	91/452 = 20%
−9p		40/246 = 19%		28/118 = 24%	7/22 = 32%	5/26 = 19%	7/40 = 18%	87/452 = 19%
−4p		32/246 = 15%		17/118 = 14%			2/40 = 5%	51/404 = 13%