Research Article

On the Meaning of Affinity Limits in B-Cell Epitope Prediction for Antipeptide Antibody-Mediated Immunity

Figure 1

IEDB B Cell Search facility interface (http://www.immuneepitope.org/advancedQueryBcell.php). Example shown corresponds to primary search for thermodynamic data (see main text for full explanation). Green squares along left margin mark user options selected from pull-down menus, for restricting searches by data fields of the type “Epitope Relation;” upper and lower green squares, respectively, mark options for “1st Immunogen Epitope Relation” (set to “Epitope” for both primary and secondary searches”) and “Antigen Epitope Relation” (set to either “Epitope” for primary searches or “Source antigen” for secondary searches). Inset with red border contains screenshot of Assay Finder pop-up window (activated by clicking the Assay Finder button, located along bottom edge of inset), which facilitates the selection of search-appropriate assay-type categories using the B-cell Assay Tree (shown in right panel of inset).
346765.fig.001