Extracellular Vesicles in the Cornea: Insights from Other Tissues

Figure 4

EV-collagen interactions in a reconstituted collagen substrate. (a) TEM image of EVs (red asterisks) distributed within the collagen matrix. A number of large collagen aggregates are attributed to PureCol collagen (white arrows) with the presence of small fibrils (yellow arrowheads). . (b) High-magnification QFDE image shows EVs (red asterisks), large fibril bundles (white arrows), and small fibril bundles (yellow arrowheads) present within the collagen matrix. . (c) Low-magnification QFDE image shows EVs (red asterisks) connected with small fibril bundles (yellow arrowheads). Large fibril bundles (white arrows) were also present. . (d) High-magnification QFDE image of an EV (vesicle) containing matrix components (white arrows). . Images were modified and reproduced from Saeidi et al. 2012 [57] based on a Creative Commons license, doi:10.1002/bit.24533.

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