Associated Biochemical and Hematological Markers in COVID-19 Severity Prediction

Table 2

Univariate and multivariate logistic regression analyses of risk factors associated with severe COVID-19.

Parameters	Univariate				Multivariate
	β	SE	95% CI		β	SE	95% CI	value
Age	1.035	0.009	1.017–1.035	0.001	1.031	0.014	1.003–1.060	0.030
Hb	0.819	0.059	0.729–0.919	0.001
RBC	0.57	0.168	0.410–0.793	0.001
PCV	0.945	0.020	0.909–0.982	0.004
TC	1.000	0.000	1.0–1.0	0.001
Neutrophil	1.100	0.017	1.065–1.137	0.001	0.844	0.085	0.714–0.997	0.047
Lymphocyte	0.895	0.020	0.861–0.930	0.001	0.828	0.095	0.688–0.9980	0.048
NLR	1.296	0.049	1.176–1.47	0.001
LMR	0.939	0.029	0.887–0.995	0.032	1.107	0.052	1.000–1.226	0.050
LCR	0.722	0.123	0.567–0.919	0.001
Ferritin	1.002	0.000	1.001–1.003	0.001
LDH	1.003	0.001	1.002–1.004	0.001	1.001	0.001	1.000–1.003	0.050
CRP	1.027	0.004	1.019–1.034	0.001	1.021	0.008	1.012–1.043	0.001
D-dimer	2.891	0.213	1.905–4.387	0.001	1.830	0.209	1.214–2.758	0.004
Urea	1.012	0.003	1.006–1.019	0.001
Creatinine	1.225	0.062	1.085–1.383	0.001
Potassium	1.785	0.239	1.117–2.851	0.015
ALT	1.018	0.005	1.008–1.028	0.001	1.026	0.008	1.010–1.041	0.001
AST	1.022	0.006	1.010–1.035	0.001
ALP	1.003	0.004	0.95–1.010	0.498

Hb: hemoglobin; PCV: packed cell volume; TC: total leukocyte count; ALT: alanine transferase; AST: aspartate transferase; ALP: alkaline phosphatase; LDH: lactate dehydrogenase; CRP-C: reactive protein; NLR: neutrophil-to-lymphocyte ratio; LMR: lymphocyte-to-monocyte ratio; PLR: platelet-to-lymphocyte ratio; LCR: lymphocyte-to-CRP ratio. value indicates the level of significance.