Unresponsiveness of Experimental Canine Leishmaniosis to a New Amphotericin B Formulation

Table 1

24 parameters clinical scoring scale of dogs infected with L. infantum.

Condition and affected organ	Clinical sign	Severity grade
		0	1	2	3
General	Appetite	Normal	Decreased	Anorexia	—
	Asthenia	Absence	Mild	Postration	—
	Fatigue	Absence	Mild	Severe	—
	Polyuria/Polydipsia	Absence	—	—	Presence
Muscles	Temporal muscles amyotrophy	Absence	Slight temporal amyotrophy	Marked temporal amyotrophy	—
	General amyotrophy	Absence	Slight amyotrphy (emaciation)	Cachexia	—
Immune system	Adenopathy	Absence	Localized	—	Generalized
	Splenomegaly	Absence	—	—	Presence
Eyes	Conjunctivitis, blepharitis, and keratitis	Absence	Mild	Severe	—
	Uveitis	Absence	—	—	Presence
Mucosae	Pale mucosae	Absence	—	Presence	—
	Epistaxis	Absence	—	—	Presence
	Oral lesions	Absence	1 or 2 ulcers and/or nodules	More than 2 ulcers and/or nodules	—
Digestive system	Vomiting	Absence	Occasional	Frequent	—
	Diarrhea	Absence	Occasional	Frequent or melena	—
Joints	Lameness and joint pain	Absence	—	—	Presence
Skin	Erythema	Absence	—	Presence	—
	Ulcers	Absence	1 ulcer or 2 ulcers	>3 ulcers	—
	Alopecia	Absence	Localized or mild	Alopecia on more than 25% of the body surface	—
	Exfoliative dermatitis	Absence	Localized	Generalized	—
	Hyperkeratosis of nose	Absence	—	Presence	—
	Hyperkeratosis of footpads	Absence	—	Presence	—
	Generalized hyperkeratosis	Absence	—	Presence	—
	Onychogryphosis	Absence	—	Presence	—