Unresponsiveness of Experimental Canine Leishmaniosis to a New Amphotericin B Formulation

Table 3

Clinical, clinicopathological, serological, and parasitological follow-up of eight dogs experimentally infected with L. infantum before (T1) and after treatment (PT6) with free polyaggregated amphotericin B.

Dog	Clinical score		Clinicopathological score		Weight		IFAT		BM cytology		BM culture		BM rtQ-PCR		Blood rtQ-PCR		Urine rtQ-PCR
	T1	PT6	T1	PT6	T1	PT6	T1	PT6	T1	PT6	T1	PT6	T1	PT6	T1	PT6	T1	PT6
1	16	22	5	5	11.2	12.3	1/6400	1/1600	+	+	+	+	24420	7140000	24535	22.5	2.02	0
2	28	17	3	6	10.1	12.3	1/6400	800	+	+	+	+	3630	106800	945	8.44	0.22	0.53
3	21	27	4	5	10	6.7	1/6400	1600	+	+	+	+	22170	639	381.5	23.4	0.31	0.14
4	16	15	6	10	16.4	19.7	1/3200	1600	+	+	+	+	44700	1272000	70000	8.73	0	0
5	5	12	2	5	18.5	11	1/1600	3200	+	+	+	+	2577	42900	0	2.4	0.23	0.11
6	9	10	7	10	15.2	15.5	1/1600	1600	+	−	+	+	9060	22680	756	2.28	0.34	0
7	25	8	6	6	11.3	12.45	1/6400	1600	+	+	+	+	26610	53700	1711.5	0.393	8.57	0.43
8	12	4	6	7	16.2	17.15	1/3200	1/100	+	−	+	−	0.3796	0.088	0	0	0	0