Acute and Subchronic Toxicity Profile of Euphorbia pulcherrima Methanol Extract on Wistar Albino Rats

Table 5

Effect of the E. pulcherrima extract on the serum level of ALAT, ASAT, ALP, T protein, albumin, and bilirubin (liver function parameters) of rats.

Liver function	Group A	Group B	Group C	Group D
Parameters	(1000 mg/Kg)	(100 mg/Kg)	(10 mg/Kg)	(Control)
Reference value	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE
ALAT (u/L); (up to 22 UI)	29.00 ± 1.48	32.00 ± 1.67	26.00 ± 2.41	32.20 ± 2.42
ASAT (u/L); (up to 218)	46.20 ± 1.88	39.80 ± 4.39	48.40 ± 7.42	49.80 ± 3.64
ALP (u/L); (60–170)	226.60 ± 17.15	220.20 ± 7.52	206.00 ± 6.50	207.00 ± 5.33
T. Protein (g/L); (58–80)	80.00 ± 0.71	80.80 ± 1.39	81.60 ± 0.75	83.00 ± 1.34
T. bilirubin (µmol/L); (1.7–17.1)	22.00 ± 1.05	21.00 ± 0.71	20.40 ± 0.60	21.40 ± 0.40
C. bilirubin (µmol /L); (1.7–8.5)	12.00 ± 0.63	11.20 ± 0.66	10.80 ± 0.58	11.60 ± 0.40
Albumin (g/L); (35–50 g)	51.80 ± 1.36	51.80 ± 1.07	51.00 ± 0.71	55.80 ± 2.31

Values are expressed as mean ± SEM for = 5. Values are considered significant if ().