Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral <i>Sinularia sandensis</i> through the MAPKs Pathway on Oral Cancer Cells

<div>4-Carbomethoxyl-10-epigyrosanoldie E reduced the expression levels of proteins associated with cell migration and invasion. (a) Western blotting analysis examined the expression levels of FAK, PKC, GRB2, Rac, Ras, RhoA, MEKK3, and MKK7 in Cal-27 and Ca9-22 cells treated with 4-carbomethoxyl-10-epigyrosanoldie E (2.5–10 <i>μ</i>M), respectively. (b) Expression levels of IQGAP1, SLUG, and ZO-1 in Cal-27 and Ca9-22 cells treated with 4-carbomethoxyl-10-epigyrosanoldie E (2.5–10 <i>μ</i>M), respectively. C means cells were treated with DMSO vehicle only. <i>β</i>-Actin was used as the protein loading control.</div>

Advances in Pharmacological and Pharmaceutical Sciences

fig4

Figure 4

Figure 4: Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral <i>Sinularia sandensis</i> through the MAPKs Pathway on Oral Cancer Cells 

Figure 4 | Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells 