Review Article
Biomechanical Influence of Cartilage Homeostasis in Health and Disease
Table 2
Clinical findings supporting a role for exercise therapy in maintaining cartilage health.
| Intervention | Duration | Subjects | Outcome | Reference |
| Aerobic walking and quadriceps strengthening exercise | 18 months | 35 subjects without knee OA | Both exercise regimen showed normal distribution of proteoglycans and reduced pain and disability from knee OA | [38] | Supervised exercise | 3 times weekly for 4 months | 45 subjects who underwent partial medial meniscus resection 3–5 years previously | Improved GAG content and reduced pain and joint symptoms | [4] | Cumulative physical exercise | Low (<6862) or high (>8654) exercise hours | 805 subjects | Reduced risk in knee OA | [41] | Recreational walking or jogging | Low versus high levels of activity | 1279 subjects, with or without knee OA; middle aged or elderly, BMI below or above median | Subjects with a high BMI had no increase in risk of OA. Overweight, middle aged, and elderly persons neither protects against nor increases risk of OA | [42] | Exercise | Various | 11 randomised control trials | Beneficial effect on pain and disability | [47] |
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