Cytotoxicity Induced by Tetracyclines via Protein Photooxidation

Figure 2

MTT test of photocytotoxicity of seven tetracycline derivatives. Significance: therapeutic agents with an IC₅₀ under 10 μM are considered extremely cytotoxic; range between 50 and 100 μM is considered moderately cytotoxic. All TCs studied in this work have noncytotoxic effect on keratinocytes with no light exposure but have toxicity effect in the presence of light. If toxicity is shown upper 200 μM, the compounds are considered safe for their therapeutic purpose.