Research Article
Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes
Table 8
IC
50 values (
g/mL) of cytotoxic activity of ligands and their metal complexes.
| | Compound | Raw | MCF-7 | COLO 205 |
| | HL1 | 46.8 | 24.5 | 20.1 | | HL2 | 56.1 | 34.2 | 39.1 | | HL3 | 52.8 | 29.2 | 15.2 | | HL4 | 46.9 | 30.4 | 68.1 | | Ni(L1)2 | 224.8 | 67.1 | 54.6 | | Ni( L2)2·H2O | 36.3 | 26.5 | 60.9 | | Ni(L3)2·H2O | 53.0 | 36.9 | 71.4 | | Ni(L4)2 | 58.6 | 35.6 | 49.9 | | Zn(L1)2·H2O | 44.0 | 40.1 | 54.7 | | Zn(L2)2 | 34.0 | 52.3 | 43.9 | | Zn(L3)2 | 33.1 | 22.6 | 42.0 | | Zn(L4)2·H2O | 42.5 | 39.2 | 53.5 | | Cis-platin | 1.5 | 1.7 | 5.6 |
|
|
