Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines

Table 1

Specific activities of TrxR, GPx, and Cat enzymes in the given period, after incubation of A549 and K562 cells, with IC₅₀ values of metal complexes.

A549			K562
		U/mg protein			U/mg protein
TrxR	Control; C1; C2; C3	0.5080^ax  ± (0.00458)^y; 0.4740^a  ± (0.00529); 0.2600^b  ± (0.01114); 0.2960^b  ± (0.00557)	TrxR	Control; C1; C2; C3	1.0640^a  ± (0.00529); 0.5867^d  ± (0.01155); 0.7200^b  ± (0.05568); 0.6070^c  ± (0.02000)
GPx	Control; C1; C2; C3	0.1520^a  ± (0.00265); 0.0680^c  ± (0.00854); 0.1067^b  ± (0.00351); 0.0460^d  ± (0.00361)	GPx	Control; C1; C2; C3	0.2367^a  ± (0.00577); 0.0200^b  ± (0.00000); 0.0000^b  ± (0.00000); 0.0000^b  ± (0.00000)
Cat	Control; C1; C2; C3	854.73^a  ± (0.00008); 281.68^c  ± (0.00005); 530.41^b  ± (0.00002); 252.36^d  ± (0.00002)	Cat	Control; C1; C2; C3	354.9300^a  ± (3.27432); 131.8900^b  ± (1.47401); 121.9100^c  ± (1.80602); 108.8163^d  ± (2.78970)

Among groups mean value ( = 3), standard deviation, Significant differences (1: ≤ 0.05; 2: ≤ 0.01; 3: ≤ 0.001) in a row.