Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells

Table 1

Cytotoxic activities of steroidal glycosides from S. nigrum on five cancer cell lines.

Compounds	IC50 (M)
	A549	H1975	H1299	PANC1	MIA-PaCa2
1	4.9 ± 1.0	5.5 ± 0.6	6.3 ± 0.8	2.9 ± 0.2	6.4 ± 0.4
2	>30	>30	>30	>30	>30
3	>30	>30	27.9 ± 3.0	>30	>30
4	28.4 ± 3.1	>30	>30	>30	>30
Camptothecin	1.5 ± 0.9	0.16 ± 0.1	0.24 ± 0.1	4.7 ± 0.5	3.3 ± 0.2

IC₅₀ values were calculated in a triplicate experiment.
used as positive control.