Research Article

Novel Target Study to Cure Cardiovascular Disease regarding Proprotein Converse Subtilisin/Kexin Type 9

Table 1

Top 20 ranked compounds with higher LibDock scores than PCSK9.

NumberZINC IDCompoundsLibDock score

1ZINC0000622382225-Methyltetrahydropteroyltri-L-glutamate239.613
2ZINC000085544839Thf-polyglutamate238.17
3ZINC000095620524Tetra-trans-P-coumaroylspermine226.594
4ZINC000004099069S-(pga1)-glutathione206.719
5ZINC0000046548453-Hexaprenyl-4-hydroxybenzoate205.355
6ZINC000085541163(+-)-Grossamide204.523
7ZINC000008552069Thf-L-glutamate202.145
8ZINC0000135135401,14-Bis(dihydrocaffeoyl)spermine201.87
9ZINC0000042282935-Formiminotetrahydrofolate201.743
10ZINC000009212428Leucal200.227
11ZINC000014952116Enkephalin197.698
12ZINC000014712793Kukoamine B196.511
13ZINC000011616636Hibon196.025
14ZINC0000082200362-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone195.582
15ZINC000004096653Dhhpba195.52
16ZINC000012494317Isodesmosin192.893
17ZINC000014951658Endomorphin 1192.844
18ZINC000085826835(+-)-Grossamide192.709
19ZINC000042805482Grossamide192.559
20ZINC000004097774Lithospermic acid192.238