Novel Target Study to Cure Cardiovascular Disease regarding Proprotein Converse Subtilisin/Kexin Type 9

Table 5

Hydrogen bond interaction parameters for potential compounds and PCSK9.

Receptor	ZINC ID	Donor atom	Receptor atom	Distances (Å)
PCSK9	ZINC000004099069	B:ARG476:HH11	ZINC000012494317:N22	2.52581
		ZINC000012494317:H38	B:ARG357:O	2.05695
		ZINC000012494317:H38	B:VAL359:O	2.3965
		ZINC000012494317:H39	B:VAL359:O	2.0501
		ZINC000012494317:H57	B:CYS477:O	2.32261
		ZINC000012494317:H60	B:GLU332:OE2	2.18568
		ZINC000012494317:H71	B:ILE474:O	2.08114
		ZINC000012494317:H84	B:PRO331:O	2.25439
		ZINC000012494317:H86	B:PRO331:O	2.22788
		ZINC000012494317:H86	B:VAL333:O	2.64061
		ZINC000012494317:H87	B:VAL333:O	2.1696
		ZINC000012494317:H87	B:ASP360:OD2	2.22538
		ZINC000012494317:H89	B:LEU436:O	1.85936
		ZINC000012494317:H90	B:LEU436:O	2.0148
		B:PRO331:HA	ZINC000012494317:N31	2.49123
		B:TRP461:HD1	ZINC000012494317:O36	2.22741
		B:ALA478:HA	ZINC000012494317:O16	2.67059
		ZINC000012494317:H48	B:ARG357:O	2.56198
		ZINC000012494317:H59	B:PRO331:O	2.82566
		ZINC000012494317:H85	B:CYS358:O	2.49137
		ZINC000012494317:H85	B:ASP360:OD2	2.83867
		ZINC000012494317:H88	B:THR459:O	2.44502
	ZINC000014952116	B:ARG357:HH12	ZINC000014952116:O8	2.89478
		B:ARG357:HH22	ZINC000014952116:O40	1.86693
		B:ARG458:HH11	ZINC000014952116:O35	2.07486
		B:ARG458:HH12	ZINC000014952116:O23	2.05105
		B:TRP461:HN	ZINC000014952116:O27	2.7019
		ZINC000014952116:H60	ZINC000014952116:O23	1.92783
		ZINC000014952116:H63	B:ARG357:O	1.9849
		ZINC000014952116:H68	B:LEU436:O	1.85726
		ZINC000014952116:H74	B:ASP360:OD1	2.1021
		B:PRO331:HA	ZINC000014952116:O19	2.69646
		B:VAL460:HA	ZINC000014952116:O27	2.85792
		B:TRP461:HD1	ZINC000014952116:O27	2.13275
		ZINC000014952116:H61	B:ASP360:OD1	2.55504
		ZINC000014952116:H62	B:CYS358:O	2.45617
		ZINC000014952116:H62	B:ASP360:OD2	3.01446
		ZINC000014952116:H65	B:ARG357:O	2.40176
		ZINC000014952116:H77	ZINC000014952116:O8	2.41561
		B:ARG458:HH22	ZINC000014952116	2.79122