Association between Interleukin-6 Gene Polymorphism (rs1800795 and rs1800796) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case-Control Study in the Ho Municipality

Table 4

Association of rs1800795 and rs1800796 polymorphism with the risk of type 2 DM.

Variables	Controls	All cases	Crude model		Adjusted model
			cOR	value	aOR	value
rs1800795
GC vs. GG	40 (33.1)	96 (56.8)	2.74 (1.68-4.46)	<0.001	2.35 (1.13-4.90)	0.022
Allele (C vs. G)	40 (33.1)	96 (56.8)	2.80 (1.72-4.55)	<0.001	2.41 (1.16-5.00)	0.019
rs1800796
GC vs. GG	29 (20.0)	108 (63.9)	7.08 (4.24-11.84)	<0.001	8.67 (4.00-18.90)	<0.001
Allele (C vs. G)	29 (20.0)	108 (63.9)	7.08 (4.24-11.84)	<0.001	8.84 (4.06-19.26)	<0.001

Data are presented as frequency with corresponding proportion in parenthesis or odd ratio with 95% confidence interval. cOR: crude odd ratio; aOR: adjusted odd ratio. Adjusted model: multivariate logistic model involving age, dietary sugar intake and educational status, work status, anthropometric indices, and systolic and diastolic blood pressures treated as covariates. is significant. Significant values are marked in bold.