Genome-Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.

Figure 5

Visualization of the hub genes using five different calculation methods. (a) Bar plot to identify significant top 13 hub genes using five intersecting algorithms (betweenness, closeness, degree, MCC, and MNC) for differentially expressed ARGs in Shigella genomes. (b) Four hub proteins (e.g., tolC, acrR, mdtA, and gyrA) were found to be shared in the five methods.

(a)

(b)