Genome-Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.

Table 2

Topological information of hub proteins as determined by five distinct algorithms.

Proteins	Full name	MCC	MNC	Degree	Closeness	Betweenness	Stress
cpxA	Sensor histidine kinase	6	3	5	17.67	124.93	230
soxR	Superoxide response regulon	121	5	6	17.75	64	118
emrB	Multidrug resistance protein B	22	7	7	18.58	67.167	162
gyrA	DNA gyrase subunit A	35	7	8	19.33	145.73	322
marR	Multiple antibiotic resistance regulator	162	9	9	19.67	26.3	78
marA	Multiple antibiotic resistance activator	144	6	6	18.17	5	24
acrR	Acriflavine resistance regulator	158	9	9	19.83	79.93	184
acrE	Acriflavine resistance protein E	26	7	7	18.33	17.73	66
tolC	Outer membrane efflux protein	249	20	21	26.67	623.5	1,114
mdtA	Multidrug transporter protein A	84	11	11	20.58	68.67	202
mdtC	Multidrug transporter protein C	20	6	6	17.67	8.93	50
acrB	Acriflavine resistance protein B	20	6	6	17.67	8.93	50
acrA	Acriflavine resistance protein A	24	6	6	17.67	2.2	12

MCC: maximum clique centrality; MNC: maximum neighbourhood component.