Research Article
Genome-Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.
Table 2
Topological information of hub proteins as determined by five distinct algorithms.
| Proteins | Full name | MCC | MNC | Degree | Closeness | Betweenness | Stress |
| cpxA | Sensor histidine kinase | 6 | 3 | 5 | 17.67 | 124.93 | 230 | soxR | Superoxide response regulon | 121 | 5 | 6 | 17.75 | 64 | 118 | emrB | Multidrug resistance protein B | 22 | 7 | 7 | 18.58 | 67.167 | 162 | gyrA | DNA gyrase subunit A | 35 | 7 | 8 | 19.33 | 145.73 | 322 | marR | Multiple antibiotic resistance regulator | 162 | 9 | 9 | 19.67 | 26.3 | 78 | marA | Multiple antibiotic resistance activator | 144 | 6 | 6 | 18.17 | 5 | 24 | acrR | Acriflavine resistance regulator | 158 | 9 | 9 | 19.83 | 79.93 | 184 | acrE | Acriflavine resistance protein E | 26 | 7 | 7 | 18.33 | 17.73 | 66 | tolC | Outer membrane efflux protein | 249 | 20 | 21 | 26.67 | 623.5 | 1,114 | mdtA | Multidrug transporter protein A | 84 | 11 | 11 | 20.58 | 68.67 | 202 | mdtC | Multidrug transporter protein C | 20 | 6 | 6 | 17.67 | 8.93 | 50 | acrB | Acriflavine resistance protein B | 20 | 6 | 6 | 17.67 | 8.93 | 50 | acrA | Acriflavine resistance protein A | 24 | 6 | 6 | 17.67 | 2.2 | 12 |
|
|
MCC: maximum clique centrality; MNC: maximum neighbourhood component.
|