An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy

Figure 1

Spatially explicit half-sarcomere model (modified from [24]). (a) Schematic of the half-sarcomere showing the myosin filament (red), actin filament (blue), titin (green), Z-disk (black), and crossbridges (red). (b) Spatial hexagonal arrangement of myosin and actin filaments. (c) Mathematically, the half-sarcomere is modelled as an array of springs: myosin and crossbridges (red), actin (blue), and titin (green).

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