An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy

Figure 4

Force-pCa relationship. Simulated force-pCa relationship in control and HCM. Relative force is normalised to the maximum value that can be attained. Inset: experimental force-pCa relation of skinned HCM and control preparations obtained from human patients [17].