An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy

Table 1

Hypertrophic cardiomyopathy (HCM) functional changes [16, 17] made to the electromechanical single-cell model.

Parameter	HCM
Volume	+100%
Capacitance	+59%
	+107%
	-34%
	-27%
	-85%
	-15%
	+19%
	+34%
SERCA	-43%
CaMKa	+350%
PLB	-40%
Hill coefficient	-50%

Change made to the myofilament model of the coupled single model. is the maximum conductance of the late sodium current, is the maximum conductance of the rapid delayed rectifier K⁺ current, is the maximum conductance of the slow delayed rectifier K⁺ current, is the maximum conductance of the rapid delayed rectifier K⁺ current, is the maximum conductance of the transient outward K⁺ current, is the maximum conductance of the inward rectifier K⁺ current, is the maximum conductance of the Ca²⁺ current through the L-type Ca²⁺ channel, is the maximum conductance of the Na⁺/K⁺ exchange current, SERCA is the sarco/endoplasmic reticulum Ca²⁺-ATPase pump, CaMKa is the fraction of active Ca²⁺/calmodulin-dependent protein kinase II binding sites, PLB is phospholamban, and the Hill coefficient is a measure of the Ca²⁺ sensitivity of the cardiomyocyte.