Research Article
An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy
Table 1
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Change made to the myofilament model of the coupled single model. is the maximum conductance of the late sodium current, is the maximum conductance of the rapid delayed rectifier K+ current, is the maximum conductance of the slow delayed rectifier K+ current, is the maximum conductance of the rapid delayed rectifier K+ current, is the maximum conductance of the transient outward K+ current, is the maximum conductance of the inward rectifier K+ current, is the maximum conductance of the Ca2+ current through the L-type Ca2+ channel, is the maximum conductance of the Na+/K+ exchange current, SERCA is the sarco/endoplasmic reticulum Ca2+-ATPase pump, CaMKa is the fraction of active Ca2+/calmodulin-dependent protein kinase II binding sites, PLB is phospholamban, and the Hill coefficient is a measure of the Ca2+ sensitivity of the cardiomyocyte. |