Humans are complex organisms designed to respond to different internal, external, or contextual stressors through a variety of complex mechanisms. As a species, humans have developed one of the most advanced alert and preparedness systems on the planet. This system integrates and mobilizes resources from all the main organs of the body, allowing us to survive and create a human being highly adaptive to the different contextual stressors experienced during its evolution as a species.

However, in the last phases of this evolution, rapid contextual change has occurred, whereby these responses that are highly adaptive to primitive contexts now become the basis of disruptions and pathologies. Improving our understanding of the effect of contextual stressors in the psychophysiological stress response helps us better understand stress-related diseases and pathologies. The monitoring, evaluation, and control of physiological and psychological variables are transforming the landscape for researchers and practitioners to provide scalable and reliable assessment and treatment to individuals across a diverse spectrum of disciplines. Thus, a psychophysiological perspective offers many opportunities for advancement in the fields of medicine, nutrition, psychology, and physical performance. Specific contextual stressors increase the stress response of an organism, being modulated by different factors including nutrition, psychological profile, or environment stressors. Stress response is a complex, multifactorial response in which several factors modulate the results and the response of the subject. Traditionally, it has been approached from different isolated areas, giving a partial approach to this broad construct that affects so many areas.

This Special Issue aims to bring together, under a holistic and integrative perspective, the different areas related to the complex phenomenon of stress and how different factors can affect this response. In this Special Issue, we intend to carry out a multidisciplinary approach, according to the current literature on the subject, and give a broader and more realistic understanding of stress in current times. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

• Nutrition, gut health, nutritional habits, and stress.
• Physical fitness status and stress response
• Body composition, stress, and health
• Psychological profile and stress response
• Psychophysiology of stress
• Environmental stressors
• New methodologies to monitor stress responses
• Odontology, stress, and health