Cancer radiotherapy has been largely driven by technological development in the past thirty years, resulting in enhanced local tumor control. Yet, the paradigm has shifted more recently toward a patient-centered health care model where success is measured by improved treatment outcome, increased patient safety, and higher patient satisfaction. Ideally, treatment outcome and patient safety should be strived for simultaneously with local tumor control in the clinic in order to maximize therapeutic ratio while maintaining a high standard of patient care.

This special issue is intended to present novel technological breakthroughs and state-of-the-art developments in cancer radiotherapy in recent years, which could hold great potential for improved treatment outcome and patient safety in the radiotherapeutic management of cancers worldwide.

Potential topics include, but are not limited to:

• Advanced imaging for treatment response assessment
• Adaptive radiotherapy for improved treatment outcome and patient safety
• Advanced tumor tracking and monitoring
• Online quality assurance of treatment delivery
• Advanced algorithms for real-time monitoring of patient safety
• Biologically guided radiation therapy
• Electronic health record data mining for more efficient radiotherapy
• Novel treatment modality for improved treatment outcome and patient safety