Though chronic pain is high invalidating conditions, it is hardly assessed in patients affected by neurodegenerative disorders, especially when associated with cognitive and affective disturbances. Evidence of pain related symptoms in neurological diseases with prevalent motor involvement, as Parkinson’s disease, or cognitive impairment, as Alzheimer disease, is increasing over time, though pathophysiological basis, clinical appearance, and methods to improve clinical assessment need to be further clarified. Both clinical scales and neurophysiological and psychophysical measures could improve our knowledge on this important but still unresolved aspect of neurodegenerative diseases, providing further opportunities for the improvement of the management of such diffuse and invalidating disorders.

Editors are pleased to launch this new special issue, which is intended to present and discuss current knowledge about clinical aspects of pain in different neurodegenerative disorders, main evidences from experimental pain researches, and new results from clinical, neurophysiological, psychophysical, and therapeutic tests aiming to improve the knowledge on this important aspect of neurological disorders.

Potential topics include, but are not limited to:

• Review on main clinical assessment methodologies
• Clinical guidelines
• Epidemiological and clinical studies
• Treatment options
• Neurophysiological assessment
• Psychopathological aspects
• Costs and social impacts