Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus

Figure 3

Nuclear regulation of p53 during late torpor. (a) Western blot is shown for nuclear levels of p53 and histone H3 during euthermic control and late torpor. (b) p53 DNA binding activity towards double stranded probe containing p53 consensus binding sequence (5′-GGACATGCCCGGGCATGTCC-3′) in control and late torpor nuclear lysates. Data show mean ± SEM, independent trials on tissues from different animals. denotes significant statistical difference from EC values, .

(a)

(b)