Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Figure 4

Flow cytometry of human platelet rich plasma incubated with 0.01 mg/mL and 0.001 mg/mL of silica nanoparticles (SiNPs). Distribution of platelets according to their shape and granulation. SS LOG, parameter of platelets granulation: FS LOG, parameter of platelets shape. (a) Resting platelets incubated with equal volume of TBS as a control; (b) resting platelets incubated with 0.001 mg/mL of SiNPs (silica nanoparticles) during 5 min; (c) platelets activated by thrombin (0,125 NIH/mL) for 2 min; (d) platelets activated by thrombin, preincubated with 0.01 mg/mL of SiNPs during 5 min.

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