Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model
Figure 2
Immunohistochemical detection of inflammation in the heart. Light micrographs of heart sections from rats treated as outlined in Materials and Methods Section and Table 2. In LID-fed rats (Groups 1–6 (G1–G6)), DOX treatment (G5) increased positive immunostaining (arrows) for interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) compared to saline treatment (G6), whereas FCM administration to DOX-treated rats (G1–G4) reduced levels of IL-6 and TNF-α compared to DOX treatment alone (G5). For IL-6, FCM treatment reduced staining levels below that of LID alone (G6). In ND-fed rats (G7 and G8), treatment with DOX and FCM (G8) greatly increased positive immunostaining compared to ND alone (G7). (a) and (b) original magnification, ×400.
