Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model

Table 5

Histomorphometric assessment of the heart according to iron diet, DOX treatment, and supplementation with FCM.

	Group
	1	2	3	4	5	6	7	8
Parameter
Masson’s trichrome (% area)	13.7±1.1^∗	14.3±1.4^∗	13.0±1.2^∗	12.1±1.4^∗	17.4±0.9^‡	11.7±1.8^‖	8.1±1.2^¶	20.9±1.2
Sirius Red (% area)	10.3±1.1^∗	9.9±1.4^∗	9.8±1.3^∗	9.3±1.1^∗	15.9±1.1^‡	11.0±1.2^‖	7.8±1.3^¶	19.3±1.8
Cardiomyocyte width (µm)	31.7±1.1^†	31.3±1.2^†	31.6±1.1^†	31.0±1.0^†	35.2±0.9^‡	33.4±0.4^‖	31.1±0.9^†	31.4±0.9^†
Cardiomyocyte density (𝑛/area)	26.7±0.8^†	27.1±1.0^†	26.8±0.8^†	27.2±0.8^†	20.1±1.6^§	25.2±0.7	27.1±0.7^†	26.9±0.8^†
Capillary density (𝑛/area)	18.5±0.7^†	19.0±1.0^†	18.8±0.9^†	19.1±0.7^†	12.3±1.1^§	17.1±1.0	19.1±1.3	18.9±1.1
Cardiomyocyte/capillary ratio	0.71±0.03^†	0.71±0.03^†	0.70±0.02^†	0.70±0.03^†	0.61±0.01^§	0.67±0.03	0.71±0.03^†	0.70±0.04^†

Data presented as mean ± SD. A brief tabular overview of treatments in Groups 1–8 is included in Table 2. Further details are described in the Materials and Methods Section.
^∗𝑃<0.01 versus G5, G6, G7, and G8; ^†𝑃<0.01 versus G5 and G6; ^‡𝑃<0.01 versus G6, G7, and G8; ^§𝑃<0.01 versus G6; ^‖𝑃<0.01 versus G7 and G8; ^¶𝑃<0.01 versus G8.