Protective Effect of Quercetin on Melphalan-Induced Oxidative Stress and Impaired Renal and Hepatic Functions in Rat

Table 2

Protective effects of quercetin on melphalan-induced changes in the levels of plasma creatinine, urea, and bilirubin levels in rats.

Treatment	Creatinine (mg/dL)	Urea (mg/dL)	Bilirubin (mg/dL)
CTRL	0.98 ± 0.13	51.36 ± 0.23	0.36 ± 0.01
MPLN	2.14 ± 0.11 (188%)^*	103.9 ± 0.19 (102.3%)^*	0.80 ± 0.02 (122.2%)^*
MPLN + QCT-P	1.76 ± 0.09^*†	76.9 ± 0.64^*†	0.55 ± 0.02^*†
MPLN + QCT-C	1.52 ± 0.08^*†	95.8 ± 0.84^*†	0.51 ± 0.01^*†
QCT-A	1.38 ± 0.08^*†	74.2 ± 1.30^*†	0.46 ± 0.01^*†

Data represent the means ± SD for five rats in each group; ^*significantly different from the CTRL; ^†significantly different from MPLN. Values in parenthesis represent percentage (%) increase.