Case Reports in Nephrology / 2022 / Article / Tab 1 / Case Report
An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature Table 1 Laboratory findings on admission.
Reference range/Unit WBC 6920 U/L Hemoglobin (Hb) 11 12–16 g/dL Platelet count (PLt) 131 103 /uL Reticulocytes count 2.77 2–4% Erythrocyte count 3.56 4.2–5.8 106 /uL Lactate dehydrogenase (LDH) 180 135–214 IU/L Coombs test Negative NA Total bilirubin 0.5 0.1–1 mg/dL Total protein (TP) 5.5 6.4–8.7 g/dL Serum albumin (Alb) 2.56 3–5.5 g/dL GOT 21 5–32 IU/L GPT 12 5–33 IU/L Urea 98 17–60 mg/dL Creatinine 1.67 0.6–1.2 mg/dL Na 138 135–145 mmol/L K 5.2 3.5–5.5 mmol/L Cl 99 95–110 mmol/L CRP 1.5 0.1–0.5 mg/dL Hbs-Ag Negative NA HCV-Ab Negative NA HIV Negative NA CH50 50 40–90 U/ml CFH 250 225–760 μ g/mL Autoantibodies CFH Negative <18 AU/L C3 nephritic factor (C3NF) Negative Ratio >1.022 C3 116 90–180 mg/dL C4 22.5 10–40 mg/dL RF Negative <15 IU/ml ANA, anti-dsDNA, ANCA, and cryoglobulin Negative NA Anti-GBM Negative <1 AI Anti-PLA2R Ab (ELISA) Negative NA Beta 2 microglobulin 1.09 <0–20 mg/dL IgG 1200 800–1600 mg/dL IgA 151 70–400 mg/dL IgM 67.7 90–180 mg/dL UPCR 7614.94 <20 mg/g UACR 2635.39 <30 mg/g Urine red blood cells 15–25 /HPF 24 h urine total protein excretion 7.72 <0.15 g/24 h SPEP M-protein concentration 2 M-protein: 1.5 and 2.9% NA SIF IgG κ , IgG λ NA Urine immunofixation electrophoresis IgG λ NA mg/dL Urine IgG 52.70 NA mg/dL FLC κ 30.1 4.90–13.70 mg/L FLC λ 53 7.60–19.50 mg/L FLC κ /λ 0.57 0.27–1.67
AI: activity index; AU: arbitrary units; NA: not applicable; WBC: white blood cells; GOT: glutamate-oxaloacetate transaminase; GPT: glutamate pyruvate transaminase; Na: sodium serum; K: potassium serum; Cl: chloride serum; CRP: C—reactive protein; CH50: complement hemolytic activity-50; CFH: complement factor H; C3NF: complement-3 nephritic factor; C3: complement-3; C4: complement-4; RF: rheumatoid factor; ANA: antinuclear antibody; anti-dsDNA: anti-double stranded DNA antibody; ANCA: anti-neutrophil cytoplasmic autoantibody; anti-GBM: anti-glomerular basement membrane; anti-PLA2R Ab: anti-phospholipase a2 receptor antibody; Ig: immunoglobulin; UPCR: spot urine protein-to-creatinine ratio; UACR: spot urine albumin-to-creatinine ratio; ELISA: enzyme-linked immunosorbent assay; SPEP: serum protein electrophoresis; SIF: serum immunofixation; FLC: free light chain; κ : kappa; λ : lambda; HPF: high-power field.
