TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review

Figure 2

(A) Interstitial mononuclear inflammatory infiltrate, of lymphocytic predominance; also seen is tubular involvement with destruction (tubulitis). Hematoxylin-Eosin, 400x. (B) The inflammatory infiltrate expands the interstitium, separating the tubules, some of which show atrophic changes, evidenced by a thickened and irregular basement membrane, highlighted in blue in this trichrome stain, 200x. (C) Normal glomeruli, without increase in cellularity nor mesangial or capillary wall damage. To the left of the glomerulus, there is the inflammatory infiltrate, limited by Bowman’s capsule. Trichrome stain, 400x. (D) Electron microscopy (EM) revealing normal glomeruli, with normal podocytes, basal membrane, and endothelium. EM, 2500x.