Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient

Figure 2

Histologic and IHC findings. (a) Malignant tumor with extensive necrosis, mostly composed of large tumor cells with enlarged hyperchromatic nuclei and eosinophilic to clear cytoplasm (hematoxylin and eosin stain, ×20). (b) HCG is immunopositive in the cytoplasm of tumor cells (×20). (c) SALL-4 is positive in the nucleus of most tumor cells (×20). (d) GATA-3 is firmly nucleus positive in mononuclear trophoblast cells (×20). (e) P40 are nucleus positive in mononuclear trophoblast cells (×20). (f) CK pan is diffused and strongly positive in the cytoplasm of tumor cells (×20). (g) TTF-1 IHC is negative in the tumor cells (×20). (h) D2-40 is negative in the tumor cells (×20). HCG: human chorionic gonadotropin; GATA-3: anti-GATA3 antibody; CK pan: pankeratin; TTF-1: thyroid transcription factor 1.

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