A Case of an Elderly Woman Who Developed Corneal Perforation in the Clinical Course of Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Table 2

Previously reported AAV cases with ocular lesions (CRP and ANCA data available).

	Age	Sex	ANCA type	ANCA titer	CRP (mg/dL)	Ocular manifestation	Organ involvement	Treatment
[16]	52	M	P	Positive	16.7	Scleritis	Neuropathy	PSL, mPSL, CY, MTX
[16]	59	F	P	219 EU	>10	Scleritis	Kidney	PSL
[16]	42	M	P	>640 EU	3.1	Scleritis	Lung	PSL, mPSL, CY
[21]	73	F	MPO	235 U/mL	10.4	Bilateral orbital apex syndrome	ENT	PSL, mPSL, MTX
[22]	69	F	MPO	124 RU/mL	0.4	Scleritis	ENT	PSL, mPSL, RTX, AZA
Current case	74	F	MPO	22.0 U/mL	0.01	Scleritis, cornea ulcer, perforation	—	PSL, mPSL, MZR, RTX
[17]	54	M	C	Positive	Elevated	Necrotizing scleritis, uveitis	ENT	PSL, mPSL, MTX
[17]	56	M	C	Positive	16.8	Necrotizing scleritis, ulcerative keratitis	—	PSL, mPSL, CY
[17]	50	F	C	Positive	13.7	Necrotizing scleritis, ulcerative keratitis, cornea ulcer	Lung	PSL, mPSL, CY, MTX
[17]	30	M	C	Positive	43.0	Necrotizing scleritis, ulcerative keratitis	ENT, lung, kidney	PSL, CY, IVCY
[12]	37	M	C	Positive	7.7	Scleritis, corneal perforation conjunctivitis	ENT, lung	IVCY, CY, mPSL
[23]	38	M	C	Positive	7.2	Conjunctivitis, episcleritis, anterior uveitis	Kidney	PSL, mPSL, RTX, PE
[24]	53	F	PR3	175 IU/mL	1.2	Episcleritis	Kidney, muscle, joint	PSL, CY, AZA
[19]	67	M	PR3	23 EU/mL	0.2	Scleritis	ENT	PSL, mPSL, IVCY, RTX
[25]	44	F	PR3	5.9 U/mL	0.12	Scleritis	ENT, skin	PSL, mPSL
[26]	73	F	PR3	725 U/mL	0.4	Scleritis	Kidney, lung	PSL, RTX
[18]	40	F	PR3	195 AU/mL	6.6	Ulcerative keratitis	ENT, lung	PSL, CY
[20]	19	F	PR3	Positive	11.0	Necrotizing scleritis, ulcerative keratitis	ENT	PSL, AZA, RTX, MTX
[27]	74	M	P and C	28 EU/mL and 23 EU/mL	0.05	Scleritis	—	PSL, mPSL

AAV: antineutrophil cytoplasmic antibody-associated vasculitis, ANCA: antineutrophil cytoplasmic antibody, AZA: azathioprine, CRP: C-reactive protein, CY: cyclophosphamide, ENT: ear, nose, and throat, ESR: erythrocyte sediment rate, F: female, IVCY: intravenous cyclophosphamide, M: male, MPO: myeloperoxidase, mPSL: methylprednisolone, MTX: methotrexate, PE: plasma exchange, PR3: proteinase 3, PSL: prednisolone, RTX: rituximab.