Case Report

Metastatic Tumor of the Spermatic Cord in Adults: A Case Report and Review

Table 1

Reports of metastatic tumors of the spermatic cord in adults since 2000.

Case numberAuthor (year)Age SiteSymptomsTumor size (SC) in diameter, cmPrimary siteDuration of detection of SC metastasis from primary site diagnosis Histopathology (SC tumor)Involved structureTreatment (SC tumor)Prognosis after treatment

1Ota et al. [5] (2000) 51LeftPainless scrotal swelling2.5Stomach9 yearsPoorly differentiated adenocarcinomaEpididymis and parietal tunica vaginalisRadical orchiectomy + chemo (MTX, 5-FU)Died, 1 year

2Polychronidis et al. [6] (2002) 63LeftPainless scrotal swelling2Colon (sigmoid)OccultMucus-secreting adenocarcinomaIntactRadical orchiectomyND

3Bawa et al. [7] (2003)85LeftIncidentally found by castration NDProstate SynchronousAdenocarcinomaVas deferensRadical orchiectomy + hormone therapyND

4Salesi et al. [8] (2004) 62LeftMass in scrotumNDGastrointestinal tractOccultAdenocarcinomaEpididymitisOrchifunicolectomy + chemo (CDDP, Epirubicin, 5-FU)Died, 5 months

5Bandyopadhyay et al. [9] (2005) 67RightMass in groinNDPancreasSynchronousModerately differentiated adenocarcinomaNDRadical orchiectomy + distal pancreatectomy ND

6Kaya et al. [10] (2006) 62LeftPainful mass in inguinal site4.5Lung SynchronousNon-small cell adenocarcinomaIntactRadical orchiectomyDied, 2 weeks

7Shida et al. [11] (2006)75LeftMass in inguinal site5Colon (ascending)2 monthsPoorly differentiated adenocarcinomaIntactRadical orchiectomyDied, 6 months

8Miyake et al. [12] (2007) 60RightMass in inguinal site3Colon (ascending)1 year and 8 monthsModerately differentiated adenocarcinomaIntactRadical orchiectomy ND

9Paravastu et al. [13] (2007)62LeftPainless scrotal swellingND Colon (descending)SynchronousPoorly differentiated adenocarcinomaIntactRadical orchiectomy + chemo (irinotecan, fluorouracil, cetuximab)Alive, 18 months

10Galanis et al. [14] (2009)80RightPainful mass in inguinal siteNDColon (cecum, ascending, sigmoid) SynchronousAdenocarcinomaIntactRadical orchiectomy Died, early postoperative period

11Chang et al. [15] (2009) 38RightScrotal enlargement and chronic testicular painNDLiver7 monthsCholangiocarcinoma (Klatskin tumor)NDBiopsy of the spermatic cord tumor careful surveillanceAlive, 5 months

12Correa et al. [16] (2009)57LeftMass in inguinal site5Left kidneySynchronousRenal cell carcinoma clear cell typeNDRadical orchiectomy + radical nephrectomy + SunitinibAlive, 1 year

13Schaefer et al. [17] (2010) 64RightPainful mass in groin and scrotum2StomachSynchronousSignet ring cell carcinomaEpididymitis and testisRadical orchiectomy + chemo (paclitaxel, leucovorin, 5-FU: FLF regimen)Died, 1 year

14Ishibashi et al. [18] (2011)71RightMass in groin3.8Colon (cecum) 1 yearWell-differentiated adenocarcinomaIntactRadical orchiectomy + chemo (S-1) Alive, 15 months without recurrence

15Chiang et al. [19] (2011) 57RightPainful hard mass in inguinal site2Liver6 yearsHepatocellular carcinomaIntactRadical orchiectomy + adjuvant radiotherapy Alive, 6 months without recurrence

16Mohammadi et al. [20] (2011)57LeftPainless mass in high scrotal site6.5Left kidney3 yearsRenal cell carcinoma (clear cell type)NDTumor resection with preserved testisAlive, 3 months without recurrence

17Al-Ali et al. [21] (2012)77LeftInguinal and testicular painNDColon (descending)2.5 yearsAdenocarcinomaEpididymitis and capsule of the testisRadical orchiectomyND

18Lee et al. [22] (2012)57LeftMass in inguinal site4Stomach 3 yearsPoorly differentiated adenocarcinomaIntactRadical orchiectomy ND

19Watanabe et al. [23] (2013)52RightMass in inguinal and scrotal site2Stomach2 yearsPoorly differentiated adenocarcinomaNDRadical orchiectomy + chemo (CDDP)Died, 10 months

20Valizadeh et al. [24] (2013)36RightPainful mass in inguinal site1.6Small bowel OccultAdenocarcinomaNDRadical orchiectomy + small bowel tumor resection + chemo (capecitabine plus oxaliplatin regimen)Alive, 6 months without recurrence

21Kanazawa et al. [25] (2013) 66RightGroin pain 4.2Stomach1 yearModerately differentiated tubular adenocarcinomaNDTumor resection with preserved testis + chemo ND

22 Xu and Wang [26] (2013)50 BilMass in spermatic cordsNDStomach4 yearsSignet ring cell carcinomaEpididymitis and seminiferous ductRadical orchiectomyND

23Kim et al. [27] (2014), Case 149RightMass in scrotum with discomfort in spermatic cord4Stomach7 yearsMucinous adenocarcinoma with signet ring cell carcinomaEpididymitisRadical orchiectomy + chemo (folinic acid, fluorouracil, oxaliplatin; FOLFOX regimen)Alive, 26 months without recurrence

24Case 260LeftInguinal pain3.5Stomach6 yearsMucinous moderately differentiated adenocarcinomaIntactRadical orchiectomy + adjuvant radiationAlive, 20 months without recurrence

25Present study68RightPainless mass in inguinal site4.5Colon (cecum) 6 yearsModerately differentiated adenocarcinomaIntactRadical orchiectomy + chemo (S-1)Alive, 12 months without recurrence

S-1: tegafur/gimeracil/oteracil.
ND: Not document, SC: Spermatic cord.