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Case number | Author (year) | Age | Site | Symptoms | Tumor size (SC) in diameter, cm | Primary site | Duration of detection of SC metastasis from primary site diagnosis | Histopathology (SC tumor) | Involved structure | Treatment (SC tumor) | Prognosis after treatment |
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1 | Ota et al. [5] (2000) | 51 | Left | Painless scrotal swelling | 2.5 | Stomach | 9 years | Poorly differentiated adenocarcinoma | Epididymis and parietal tunica vaginalis | Radical orchiectomy + chemo (MTX, 5-FU) | Died, 1 year |
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2 | Polychronidis et al. [6] (2002) | 63 | Left | Painless scrotal swelling | 2 | Colon (sigmoid) | Occult | Mucus-secreting adenocarcinoma | Intact | Radical orchiectomy | ND |
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3 | Bawa et al. [7] (2003) | 85 | Left | Incidentally found by castration | ND | Prostate | Synchronous | Adenocarcinoma | Vas deferens | Radical orchiectomy + hormone therapy | ND |
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4 | Salesi et al. [8] (2004) | 62 | Left | Mass in scrotum | ND | Gastrointestinal tract | Occult | Adenocarcinoma | Epididymitis | Orchifunicolectomy + chemo (CDDP, Epirubicin, 5-FU) | Died, 5 months |
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5 | Bandyopadhyay et al. [9] (2005) | 67 | Right | Mass in groin | ND | Pancreas | Synchronous | Moderately differentiated adenocarcinoma | ND | Radical orchiectomy + distal pancreatectomy | ND |
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6 | Kaya et al. [10] (2006) | 62 | Left | Painful mass in inguinal site | 4.5 | Lung | Synchronous | Non-small cell adenocarcinoma | Intact | Radical orchiectomy | Died, 2 weeks |
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7 | Shida et al. [11] (2006) | 75 | Left | Mass in inguinal site | 5 | Colon (ascending) | 2 months | Poorly differentiated adenocarcinoma | Intact | Radical orchiectomy | Died, 6 months |
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8 | Miyake et al. [12] (2007) | 60 | Right | Mass in inguinal site | 3 | Colon (ascending) | 1 year and 8 months | Moderately differentiated adenocarcinoma | Intact | Radical orchiectomy | ND |
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9 | Paravastu et al. [13] (2007) | 62 | Left | Painless scrotal swelling | ND | Colon (descending) | Synchronous | Poorly differentiated adenocarcinoma | Intact | Radical orchiectomy + chemo (irinotecan, fluorouracil, cetuximab) | Alive, 18 months |
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10 | Galanis et al. [14] (2009) | 80 | Right | Painful mass in inguinal site | ND | Colon (cecum, ascending, sigmoid) | Synchronous | Adenocarcinoma | Intact | Radical orchiectomy | Died, early postoperative period |
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11 | Chang et al. [15] (2009) | 38 | Right | Scrotal enlargement and chronic testicular pain | ND | Liver | 7 months | Cholangiocarcinoma (Klatskin tumor) | ND | Biopsy of the spermatic cord tumor careful surveillance | Alive, 5 months |
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12 | Correa et al. [16] (2009) | 57 | Left | Mass in inguinal site | 5 | Left kidney | Synchronous | Renal cell carcinoma clear cell type | ND | Radical orchiectomy + radical nephrectomy + Sunitinib | Alive, 1 year |
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13 | Schaefer et al. [17] (2010) | 64 | Right | Painful mass in groin and scrotum | 2 | Stomach | Synchronous | Signet ring cell carcinoma | Epididymitis and testis | Radical orchiectomy + chemo (paclitaxel, leucovorin, 5-FU: FLF regimen) | Died, 1 year |
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14 | Ishibashi et al. [18] (2011) | 71 | Right | Mass in groin | 3.8 | Colon (cecum) | 1 year | Well-differentiated adenocarcinoma | Intact | Radical orchiectomy + chemo (S-1) | Alive, 15 months without recurrence |
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15 | Chiang et al. [19] (2011) | 57 | Right | Painful hard mass in inguinal site | 2 | Liver | 6 years | Hepatocellular carcinoma | Intact | Radical orchiectomy + adjuvant radiotherapy | Alive, 6 months without recurrence |
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16 | Mohammadi et al. [20] (2011) | 57 | Left | Painless mass in high scrotal site | 6.5 | Left kidney | 3 years | Renal cell carcinoma (clear cell type) | ND | Tumor resection with preserved testis | Alive, 3 months without recurrence |
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17 | Al-Ali et al. [21] (2012) | 77 | Left | Inguinal and testicular pain | ND | Colon (descending) | 2.5 years | Adenocarcinoma | Epididymitis and capsule of the testis | Radical orchiectomy | ND |
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18 | Lee et al. [22] (2012) | 57 | Left | Mass in inguinal site | 4 | Stomach | 3 years | Poorly differentiated adenocarcinoma | Intact | Radical orchiectomy | ND |
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19 | Watanabe et al. [23] (2013) | 52 | Right | Mass in inguinal and scrotal site | 2 | Stomach | 2 years | Poorly differentiated adenocarcinoma | ND | Radical orchiectomy + chemo (CDDP) | Died, 10 months |
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20 | Valizadeh et al. [24] (2013) | 36 | Right | Painful mass in inguinal site | 1.6 | Small bowel | Occult | Adenocarcinoma | ND | Radical orchiectomy + small bowel tumor resection + chemo (capecitabine plus oxaliplatin regimen) | Alive, 6 months without recurrence |
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21 | Kanazawa et al. [25] (2013) | 66 | Right | Groin pain | 4.2 | Stomach | 1 year | Moderately differentiated tubular adenocarcinoma | ND | Tumor resection with preserved testis + chemo | ND |
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22 |
Xu and Wang [26] (2013) | 50 |
Bil | Mass in spermatic cords | ND | Stomach | 4 years | Signet ring cell carcinoma | Epididymitis and seminiferous duct | Radical orchiectomy | ND |
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23 | Kim et al. [27] (2014), Case 1 | 49 | Right | Mass in scrotum with discomfort in spermatic cord | 4 | Stomach | 7 years | Mucinous adenocarcinoma with signet ring cell carcinoma | Epididymitis | Radical orchiectomy + chemo (folinic acid, fluorouracil, oxaliplatin; FOLFOX regimen) | Alive, 26 months without recurrence |
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24 | Case 2 | 60 | Left | Inguinal pain | 3.5 | Stomach | 6 years | Mucinous moderately differentiated adenocarcinoma | Intact | Radical orchiectomy + adjuvant radiation | Alive, 20 months without recurrence |
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25 | Present study | 68 | Right | Painless mass in inguinal site | 4.5 | Colon (cecum) | 6 years | Moderately differentiated adenocarcinoma | Intact | Radical orchiectomy + chemo (S-1) | Alive, 12 months without recurrence |
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