Malignant Peripheral Nerve Sheath Tumor of Prostate: A Rare Case Report and Literature Review

Figure 2

Microscopic findings of the transurethral resection biopsy specimen. (a) Low-power view shows spindle cells arranged in tightly packed fascicles, with alternating hypo- and hypercellular areas and geographic necrosis (H&E stain, ×40). (b) High-power view shows spindle-shaped tumor cells with hyperchromatic nuclei and frequent mitoses. Some entrapped prostatic glands are also seen (H&E stain, ×400). (c) By immunohistochemistry, the tumor cells demonstrate focal immunopositivity of S-100 protein (Immunoperoxidase, ×200) and (d) no immunoreactivity with CDK4 (Immunoperoxidase, ×200).

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