Response of Patients with Taxane-Refractory Advanced Urothelial Cancer to Enfortumab Vedotin, a Microtubule-Disrupting Agent

Figure 1

Two-dimensional structure of three microtubule-disrupting anticancer agents. These three agents share similar anticancer mechanisms: disrupting microtubule dynamics through the inhibition of tubulin polymerization. (a) Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin-10 isolated from sea hare Dolabella auricularia. (b) Paclitaxel is the most well-known naturally sourced cancer drug and is derived from the bark of the Pacific yew tree Taxus brevifolia. (c) Docetaxel is a taxoid derived from the needles of the European yew tree Taxus baccata.

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