Clinical Study
RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
Table 2
Demographic data and clinical features of the study population according to arrhythmias occurrence.
| | | Total
| Group I
| Group II
| value |
| | Demographic | | | | | | Male sex, (%) | 182 (77.4%) | 86 (85.1%) | 96 (71.6%) | 0.0177 | | Age (years) | 73 ± 8 | 73 ± 8 | 73 ± 8 | 1.0000 | | BMI (kg/m2) | 27 ± 5 | 28 ± 5 | 27 ± 4 | 0.0887 | | Current smoking, (%) | 122 (51.5%) | 53 (52.5%) | 69 (50.7%) | 0.5958 | | HF etiology | | | | | | IDCM, (%) | 83 (35.3%) | 19 (18.8%) | 64 (47.8%) | 0.0001 | | Dilated IHD, (%) | 108 (46.0%) | 42 (41.6%) | 66 (49.2%) | | | Nondilated IHD, (%) | 29 (12.3%) | 29 (28.7%) | 0 (0%) | | | Other HD, (%) | 15 (6.4%) | 11 (10.9%) | 4 (3.0%) | | | CRT, (%) | 64 (27.2%) | 18 (17.8%) | 46 (34.3%) |
0.0051 | | NYHA class, (%) | | | | | | I | 34 (14.5%) | 16 (15.8%) | 18 (13.4%) | 0.4548 | | II | 106 (45.1%) | 50 (49.5%) | 56 (41.8%) | | | III | 92 (39.1%) | 34 (33.7%) | 58 (43.3%) | | | IV | 3 (1.3%) | 1 (1%) | 2 (1.5%) | | | Comorbidities | | | | | | Hypertension, (%) | 107 (45.5%) | 50 (49.5%) | 57 (42.5%) | 0.2936 | | Diabetes, (%) | 90 (38.3%) | 40 (39.6%) | 50 (37.3%) | 0.7866 | | Dyslipidemia, (%) | 96 (40.8%) | 42 (41.6%) | 54 (40.3%) | 0.8937 | | Atrial fibrillation, (%) | 45 (19.1%) | 15 (14.9%) | 30 (22.4%) | 0.1807 | | Echo | | | | | | LVEDD, (mm) | 59 ± 10 | 60 ± 12 | 57 ± 13 | 0.0716 | | LVESD, (mm) | 47 ± 9 | 48 ± 8 | 46 ± 10 | 0.1002 | | LVEF, (%) | 33 ± 10 | 32 ± 9 | 34 ± 11 | 0.1377 | | Drug therapy | | | | | | Beta-blockers, (%) | 200 (85.1%) | 86 (85.1%) | 114 (85.1%) | 1.0000 | | ACE-inhibitors or ARB, (%) | 184 (78.3%) | 82 (81.2%) | 102 (76.1%) | 0.4247 | | Antialdosterone, (%) | 150 (63.8%) | 61 (60.3%) | 89 (66.4%) | 0.4107 | | Diuretics, (%) | 210 (89.4%) | 85 (84.1%) | 123 (93.3%) | 0.0971 | | Amiodarone, (%) | 95 (40.4%) | 61 (60.4%) | 34 (25.4%) | 0.0001 |
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ARB: angiotensin receptor blockers; BMI: body mass index; HD: heart disease; HF: heart failure; IDCM: idiopathic dilated cardiomyopathy; IHD: ischemic heart disease; CRT: cardiac resynchronization therapy; LVEDD: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic diameter.
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