Metabonomics Analysis of Myocardial Metabolic Dysfunction in Patients with Cardiac Natriuretic Peptide Resistance

Table 2

Identification of significant pathways in the HF and healthy groups.

NO.	Pathways	Total	Hits	value	Metabolites	Impact
1	Alanine, aspartate and glutamate metabolism	28	3	0.0035	Citric acid,; L-Aspartic acid,; L-Glutamic acid	0.420
2	Glutathione metabolism	28	2	0.0402	L-Pyroglutamic acid,; L-Glutamic acid	0.027
3	Arginine and proline metabolism	38	2	0.0700	4-Guanidinobutyric acid,; L-Glutamic acid	0.086
4	Vitamin B6 metabolism	9	1	0.1000	Pyridoxal	0.490
5	Arginine biosynthesis	14	2	0.0139	L-Glutamic acid,; L-Aspartic acid	0.1168
6	Citrate cycle (TCA cycle)	20	1	0.2095	Citric acid	0.090
7	Purine metabolism	65	2	0.1725	Adenosine,; Inosine	0.0036
8	Pyrimidine metabolism	39	1	0.3695	Uracil	0.074
9	Glyoxylate and dicarboxylate metabolism	32	2	0.0514	Citric acid; L-Glutamic acid	0.0318