The Dose-Dependent Effects of Spironolactone on TGF-β1 Expression and the Vulnerability to Atrial Fibrillation in Spontaneously Hypertensive Rats
Table 1
Comparison of blood pressure, heart rate, LA size, and serum potassium in rats (M±SD).
Group
Rat (number)
SBP (mmHg)
DBP (mmHg)
MBP (mmHg)
HR (bpm)
LA (mm)
K+ (mmol/L)
20-week-old
Group SL
10
186.5 ± 7.3
107.2 ± 6.6
130.2 ± 5.7
338.1 ± 15.6
3.7 ± 0.3
4.0 ± 0.4
Group SM
10
182.6 ± 8.1
108.5 ± 7.1
132.2 ± 5.2
342.2 ± 13.8
3.4 ± 0.3
4.1 ± 0.3
Group SH
10
185.2 ± 5.2
106.2 ± 6.4
130.2 ± 8.4
333.6 ± 18.6
3.7 ± 0.2
3.9 ± 0.4
Group H
10
189.2 ± 8.3
108.5 ± 8.6
138.6 ± 5.5
340.1 ± 14.7
3.8 ± 0.1#
4.2 ± 0.2
Group C
10
125.2 ± 6.4
80.3 ± 5.2
91.4 ± 6.3
342.8 ± 16.9
3.2 ± 0.4
3.9 ± 0.5
28-week-old
Group SL
10
188.2 ± 6.4
111.3 ± 7.6
132.6 ± 6.8
346.5 ± 12.4
5.2 ± 0.1
4.0 ± 0.5
Group SM
10
185.6 ± 5.3
110.2 ± 6.4
134.2 ± 5.7
348.2 ± 10.6
5.1 ± 0.9
3.9 ± 0.3
Group SH
10
186.2 ± 8.2
108.3 ± 6.2,
133.2 ± 5.2
342.2 ± 11.5
5.0 ± 0.4
3.9 ± 0.4
Group H
10
193.6 ± 10.4
110.2 ± 9.4
140.2 ± 7.8
350.2 ± 9.4
5.9 ± 0.3#
3.0 ± 0.4
Group C
10
123.6 ± 5.6
82.2 ± 6.4
92.5 ± 5.4
341.2 ± 13.4
4.9 ± 0.1
3.9 ± 0.3
Blood pressure comparison with group C, < 0.01 and < 0.05; LA size comparison with group C, # < 0.01. SBP: systolic blood pressure, DBP: diastolic blood pressure, MBP: mean arterial pressure; HR: heart rate; LA: left atrial.
