The Dose-Dependent Effects of Spironolactone on TGF-β1 Expression and the Vulnerability to Atrial Fibrillation in Spontaneously Hypertensive Rats

Table 2

Myocardial cell size and interstitial collagen volume fraction (M±SD).

Group	Rat (number)	HE staining myocardial cell size (um^2)	Masson staining interstitial collagen volume fraction (%)
28-week-old
Group SL	10	21016.25 ± 1604.41^&	16.40 ± 1.65^&
Group SM	10	29564.25 ± 2962.66^#	21.30 ± 2.80^##
Group SH	10	46453.67 ± 8480.74	23.10 ± 3.08
Group H	10	48224.75 ± 4657.69	23.40 ± 3.69
Group C	10	21783.75 ± 1730.17	15.40 ± 1.21

Compared with group C,  < 0.01; compared with group H, ^# < 0.01 and ^## < 0.05; compared with group SM, ^& < 0.05.