The Dose-Dependent Effects of Spironolactone on TGF-β1 Expression and the Vulnerability to Atrial Fibrillation in Spontaneously Hypertensive Rats
Table 4
Electrophysiological test results (M±SD) (unit: ms).
Group
Rat (number)
P-wave duration (ms)
PR interval (ms)
AERP (CL 150 ms)
AERP (CL 120 ms)
Inducibility of AF (%)
Duration of AF (s)
28-week-old
Group SL
10
34.0 ± 2.0&
54.3 ± 1.6&
57.9 ± 2.3
57.8 ± 1.9
30 (3/10)&
5.1 ± 1.6&
Group SM
10
36.3 ± 1.8##
55.6 ± 2.1##
57.5 ± 1.9
57.4 ± 2.7
60 (6/10)##
6.5 ± 1.7#
Group SH
10
38.4 ± 1.9
57.4 ± 2.0
56.4 ± 1.7
56.8 ± 3.1
80 (8/10)
8.9 ± 2.2.
Group H
10
38.9 ± 1.3
57.2 ± 1.8
56.2 ± 1.4
56.2 ± 1.7
90 (9/10)
11.5 ± 5.8
Group C
10
33.2 ± 1.2
54.0 ± 1.4
57.2 ± 1.7
56.8 ± 1.8
40 (4/10)
4.7 ± 1.2
Compared with group C, < 0.01 and < 0.05; compared with group H, # < 0.01 and ## < 0.05; compared with group SM, & < 0.05. AERP: atrial effective refractory period, CL: cycle length, AF: atrial fibrillation.
