Outcomes of Combined Heart-Kidney Transplantation in Older Recipients
Table 3
Multivariable Cox proportional hazards model for one-year mortality following combined heart and kidney transplantation.
Univariable analysis
Final multivariable model
Hazard ratio (95% CI)
value
Hazard ratio (95% CI)
value
Age (per year)
1.01 (1.00–1.02)
0.262
1.01 (1.00–1.02)
0.236
Creatinine (per mg/dL)
1.04 (0.99–1.09)
0.110
1.06 (1.01–1.12)
0.014
Total bilirubin (per mg/dL)
1.03 (1.01–1.05)
0.002
1.03 (1.01–1.05)
0.002
Mechanical ventilation at time of transplantation
3.48 (1.72–7.04)
0.001
2.85 (1.31–6.22)
0.008
Bridging method
None
Reference
Reference
Reference
Reference
Inotropes
0.67 (0.46–0.97)
0.033
0.78 (0.53–1.15)
0.210
IABP
0.95 (0.61–1.47)
0.811
1.06 (0.67–1.66)
0.807
Durable VAD
1.10 (0.78–1.56)
0.578
1.26 (0.87–1.83)
0.872
Temporary VAD/ECMO
1.44 (0.87–2.39)
0.156
1.49 (0.85–2.62)
0.852
Ischemic time (per hour)
1.19 (1.06–1.33)
0.003
1.17 (1.04–1.32)
0.007
Donor age (per year)
1.01 (1.00–1.03)
0.011
1.02 (1.00–1.03)
0.012
ECMO, extracorporeal membrane oxygenation; IABP, intraaortic balloon pump; VAD, ventricular assist device. Age as continuous variable. Only age and covariates associated with one-year mortality on univariable analysis are listed here.
