Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia

Table 1

Clinical and laboratory characteristics of patients with severe cutaneous adverse drug reaction (n = 41).

		DRESS		SJS/TEN		AGEP
		n	%	n	%	n	%
Gender
Female		11	47.8	6	54.6	4	57.1
Male		12	52.2	5	45.5	3	42.9
Age (years)	Mean (SD)	41.0 (25.4)		63.5 (24.5)		47.3 (21.2)
	Median (IQR)	41 (35)		71 (12)		40 (32)
Age group
Adult		19	82.6	10	90.9	6	85.7
Pediatric		4	17.4	1	9.1	1	14.3
Culprit medication class
Antibiotics		14	60.9	8	72.7	6	85.7
Anticonvulsants		7	30.4	2	18.2	0	0
Miscellaneous		2	8.7	1	9.1	1	14.3
Latency period (days)	Mean (SD)	17.3 (10.1)		12.1 (7.5)		3.9 (4.0)
	Median (IQR)	15 (16)		10 (13)		2 (5)
Fever ≥38.5°C		18	78.3	3	27.3	4	57.1
Facial edema		15	65.2	3	27.3	0	0
Mucosal involvement		1	4.4	8	72.7	0	0
Oral involvement		1	4.4	8	72.7	0	0
Eye involvement		0	0	5	45.5	0	0
Genital involvement		0	0	5	45.5	0	0
Enlarged lymph nodes		3	13	0	0	0	0
Eosinophilia		22	95.7	4	36.4	2	28.6
		5	21.7	2	18.2	2	28.6
Eosinophilia grade 2		17	73.9	2	18.2	0	0
Atypical lymphocytes		22	95.7	7	63.6	1	14.3
Leukocytosis		15	65.2	5	45.5	7	100
Leukopenia		2	8.7	3	27.3	0	0
Thrombocytosis		7	30.4	2	18.2	2	28.6
Thrombocytopenia		4	17.4	8	72.7	1	14.3
Abnormal liver function test		18	78.3	5	45.5	1	14.3
Abnormal renal function test		6	26.1	1	9.1	0	0
Lung involvement		1	4.4	0	0	0	0

AGEP, acute generalized exanthematous pustulosis; DRESS, drug reaction with eosinophilia and systemic symptoms; IQR, interquartile range; SD, standard deviation; SJS/TEN, Stevens–Johnson syndrome/toxic epidermal necrolysis. Grade 1 eosinophilia 700–1499/μL; grade 2 eosinophilia ≥1500/μL.