Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets

Figure 2

Effects of Staphylococcus aureus and its enterotoxin on the immune response in cutaneous T-cell lymphoma. The figure illustrates how the bacterial infection and its toxin activate JAK-STAT3 and JAK-STAT5 pathways, leading to the generation of regulatory T cells (Treg), TH2 cells, and Th17 cells, which suppress the antitumor immunity and promote chronic inflammation and genomic instability. Adapted from [23–26].