Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets
Table 2
Summary of articles describing the cutaneous microbiota in patients with cutaneous T-cell lymphoma (CTCL). The table shows the main findings and methods of each study.
Study
Type of sample
Method of analysis
Summary
Key finding
17. Zhang et al. (2021)
Skin swabs from mycosis fungoides patients
16S rRNA gene sequencing
Analysis of bacterial diversity in lesional and nonlesional skin and relation to CTCL symptoms
Alterations in the skin microbiota are associated with symptom and phenotype in mycosis fungoides
16. Dehner et al. (2018)
Skin samples from cutaneous T-cell lymphoma patients
16S rRNA gene sequencing
Investigates the role of skin microbiota as antigenic triggers for cutaneous T-cell lymphoma
Presence of Bacillus safensis only in CTCL patients
14. Salava et al. (2020)
Skin swabs from cutaneous T-cell lymphoma patients
16S rRNA and whole-genome sequencing
Explores the skin microbiome in cutaneous T-cell lymphoma using 16S rRNA and whole-genome shotgun sequencing
Cutaneous T-cell lymphoma patients have distinct skin microbiome profiles compared to healthy controls. 10 bacterial species more abundant in nonlesional skin
15. Harkins et al. (2021)
Skin samples from cutaneous T-cell lymphoma patients
Shotgun metagenomic sequency
Examines the cutaneous T-cell lymphoma skin microbiome and its shifts in certain commensal bacteria.
Higher abundance of Corynebacterium spp. and lower abundance of Cutibacterium spp. In CTCL patients
19. Hooper et al. (2022)
Cutaneous microbial changes in CTCL patients treated with UV
16S gene sequencing
Examination of microbial changes in the skin of CTCL patients treated with UV, noting differences in microbial richness and in microbial communities in response to
Differences in UV treatment response between responders and nonresponders, with specific changes in the abundance of certain bacteria.
