Depression study has seen a revolutionary change since the introduction of personality concept of temperament and character proposed by C. R. Cloninger. Harm avoidance, a temperament domain, and self-directedness, a character domain, are the two that are often referred to as correlates of clinical depression. Yet other domains of temperament and character have been studied as correlates of depression. Data from epidemiological studies provided an insight into the effects of age and gender on the chronological changes of temperament and character. Twin studies cast light on the extent of genetic contribution to the development of temperament and character. Prediction of depression treatment may be available from the profiles of temperament and character. Other correlates of depression such as early life environment and personality disorders may be interwoven with the complex ties of personality and depression.

The main focus of this special issue will be on the new extension of conceptual argument and empirical data on the link between personality and depression. This special issue will become a compilation of the newest data of this fast-growing area of psychiatric and psychological research. The topics to be covered include, but are not limited to:

• The concept of the temperament and character
• Factor structure and other measurement issues of temperament and character
• Correlations of temperament and character with clinical depression and its subtypes
• Possible mediation of the effects of a variety of risk factors on the onset of depression via temperament and character
• Depression treatment (drug treatment and psychotherapy) response predicted by temperament and character
• Suicidality and temperament and character
• Prediction of future depression by temperament and character in a prospective cohort study
• Determinants of depression-related temperament and character

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/drt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: